Super Fitness Health BlogMen and Women Pose Different Osteoporosis Effect
Several Research shows that osteoporosis in men differs a lot in women. The key reason in women is menopause and in the absence of a genuine male equivalent for it, we have to look elsewhere, according to the medicographia publication. Osteoporosis may trigger surgeries like metal-on-metal hip replacement which worries some patients with a report that it is defective but the British Medical Journal (BMJ) study finds no link between metal hips and cancer.
According to the ehealthMD website, osteoporosis is a disorder that makes bones turn more porous (less solid and less dense), which eventually makes them weaker and more brittle.
Bones infected by osteoporosis are those parts in the body that has no enough solid calcium and phosphorus, and progressively drop their backup protein structure, turn into thinner and more subtle than normal, break more easily, specifically in the spine, hip, and wrist.
Moreover, the key point to get across is the prominence of getting rid of secondary osteoporosis in men. Previously, one should exclude malignancy, such as metastasis or multiple myeloma, as well as other causes for low bone mass which do not relate to osteoporosis, such as osteomalacia and primary hyperparathyroidism.
Otherwise, the main cause of osteoporosis is hypercortisolism, due to the noxious effects of exogenous steroids on bone rather than to the comparatively rare cases of Cushing disease. It is not that glucocorticoids are especially toxic in men, but rather, they are more often prescribed in men, especially for chronic obstructive airways disease which is much more frequent than in women. Other primary causes are alcoholism and hypogonadism. On a more anecdotal level, we should also not forget hyperthyroidism and minor tubulopathy, which may cause low-grade hypercalciura and/or phosphate diabetes.
All-in-all, osteoporosis in men is secondary in around six cases in ten. In addition to these direct causes, there are also a number of risk factors. After you have excluded secondary osteoporosis, the remaining 40 percent of cases may be considered idiopathic.
Two factors need to be borne in mind here in terms of pathophysiology. The leading is deficiency in estrogen. Based on observation, what little stimulus testosterone has on bone is unintended, arbitrated by estrogen. Those men selected in random order, it has been exposed that circulating estradiol levels (which are naturally very low and may only be detected using ultrasensitive kits) correlate with BMD and thus help to explain age-related bone loss. No such correlation, or at least much lower correlation, is found with circulating testosterone levels.
In osteoporotic men, on the other hand, the data are less clear-cut, with some investigators finding no difference in circulating estradiol levels between osteoporotic men and controls. Finally, we now know that the microarchitecture of bone, which is a major aspect in female osteoporosis, is also a key factor in osteoporosis in men. This has been clearly demonstrated by Maurice Audran and his group in Anger, France, with particular regard to both steroid-induced osteoporosis and hypogonadism-induced osteoporosis in men. An ailment if left untreated may lead to surgical procedures such as hip replacement like DePuy Pinnacle.
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